3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione zinc. [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Differences in environmental stability among SARS-CoV-2 variants of concern: both omicron BA.1 and BA.2 have higher stabilityArticle Published on 2022-11-012022-11-16 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] Beta calculated Characteristics Concentration contributing to Delta difference Disinfection Disinfection effectiveness Effectiveness Efficacy environmental stability evaluate evaluated Ex vivo exhibited Gamma in vitro inactivated Infection median omicron regression analysis risk SARS-CoV-2 SARS-CoV-2 variant Spread stability survival transmissibility of SARS-CoV-2 Transmission variant variants variants of concern virus Virus survival. virus titre VoC VOCs was determined were measured Wuhan Wuhan strain [DOI] 10.1016/j.cmi.2022.05.020 PMC 바로가기
SARS-CoV-2 Infection Causes Hyperglycemia in CatsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome blood glucose cats cause Cell cells conducted contribute coronavirus coronavirus disease COVID-19 diabete diabetes dysregulation Endocrine Ex vivo exhibited experiment experimental evidence expressed High dose hyperglycemia immune protection immunized in vivo infect Infection islet Isolated lack pancrea pancreas pancreatic Patient Protein Research researcher SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA Spike protein staining tissue viruses viruses. [DOI] 10.1093/infdis/jiac143 PMC 바로가기
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulinArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] abrogation Activation acute respiratory distress addition Alter ARDS cell-free DNA circulation Clinical treatment Corticosteroids Course COVID-19 COVID-19 patient Critically ill Dexamethasone dose-dependent elevated Ex vivo Factor functions healthy controls healthy donor healthy donors IL-8 inflammatory pathway Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) lack Level Lung injury lung parenchyma modulate NET NETosis NETs neutrophil Neutrophil elastase Neutrophil extracellular trap neutrophil function Neutrophils not affect oxidative oxidative burst Patient Peripheral blood phagocytosis PMA pro-inflammatory function Proteins reactive oxygen specy reduced reduction severity syndrome targeting therapeutic therapeutic agent Tocilizumab tocilizumab. treated Treatment were assessed while with COVID-19 [DOI] 10.3389/fimmu.2022.993720 PMC 바로가기
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregatesArticle Published on 2022-10-052022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while [DOI] 10.3389/fimmu.2022.861251 PMC 바로가기
The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognitionArticle Published on 2022-09-212022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] Affect analysis Analysis Antigen antigen processing Antiviral antiviral activity CD8 Cell Cellular immune response delta variant epitope Ex vivo Express in vitro in vitro result inhibitor Mutation N-terminus neutralizing antibody omicron Protein Replication SARS-CoV-2 SARS-CoV-2 variant suppress susceptibility T cell T cells T-cell target cell TCR the SARS-CoV-2 virus treated variant variants [DOI] 10.1038/s41467-022-33068-4 PMC 바로가기
Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidityArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome addition Analysis association B cell cancer patient Cancer patients cancer treatment Case report co-morbidity Colorectal cancer Comorbidity coronavirus correlation COVID-19 demonstrated Effect evaluated Evidence Ex vivo examined exclusion experiment HCC Hepatocellular carcinoma heterogeneity highest Immune checkpoint blockade immune dysfunction immune response immune responses Immunity immunohistochemistry immunological effect Immunological memory Immunotherapy Inflammation intra-tumor heterogeneity long-term immune memory lymphocyte Macrophage infiltration memory B cell modulate multiplex nasopharyngeal swab test Patient persistence Population positive predicted profile Reinfection response SARS-CoV-2 significantly Single-cell RNA sequencing spatial localization spatial transcriptomics Support T cell T cell dysfunction tissue tissue-localized immunity. tissues transcriptomic transcriptomic analysis Tumor tumor microenvironment understanding virus while with COVID-19 [DOI] 10.3389/fimmu.2022.978760 PMC 바로가기
Replication of SARS-CoV-2 Omicron BA.2 variant in ex vivo cultures of the human upper and lower respiratory tractArticle Published on 2022-09-012022-11-16 Journal: EBioMedicine [Category] SARS, 변종, [키워드] airway antibody bronchial Bronchial tissue characterized China clinical manifestation Committee comparable Culture Delta delta variant disease severity Ex vivo explain explained Hong Kong human lung tissue immune evasion Infectious disease Lower respiratory tract lung lung tissue nasal nasal tissue observation omicron Omicron BA.2 parenchymal pathogenicity Patient Region replaced replicated Replication respiratory tissue SARS-CoV-2 strain Strains supported tested tissue Transmissibility Transmission. university variant virus viruses wild-type wild-type virus [DOI] 10.1016/j.ebiom.2022.104232 PMC 바로가기
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article